We have broad interests in systems biology and biotechnology. Our research is currently focusing on understanding and controlling bacterial biofilm formation. Biofilms are highly hydrated structures comprised of a polysaccharide matrix secreted by the bound bacterial cells attached to surfaces in natural, engineering, and medical environments. Whilst some biofilms have useful applications (e.g., bioremediation), most of these ubiquitous bacterial communities are problematic since they cause device-related infections, bacterial drug resistance, and microbial-induced corrosion. It is well documented that the biofilm cells are up to 1000 times more resistant to environmental stresses and disinfection treatments than planktonic (free-swimming) cells. Although the planktonic cells can be easily eradicated by disinfectants, the biofilm cells could survive and therefore provide a source of recontamination. Biofilm formation is a dynamic process including initial attachment, maturation and detachment.

The process of biofilm formation

We are currently focusing on the following areas by integrating experimental study and modeling analysis:

1. Understand the genetic basis of biofilm formation

2. Develop novel strategies for biofilm control including surface modification